A?nationwide?multicenter,?randomized?controlled?study?has?confirmed?that?after?intensive?insulin?therapy,?adopting?a?simplified?oral?hypoglycemic?drug?regimen?for?sequential?treatment?can?maintain?treatment?benefits?and?achieve?the?goal?of?optimizing?long-term?blood?glucose?control.?This?diagnostic?and?treatment?approach?is?known?as?the?"intensive-simplified"?new?treatment?strategy,?according?to?an?announcement?released?by?the?First?Affiliated?Hospital?of?Sun?Yat-sen?University?recently?(FAH-SYSU).

The?research?findings?were?published?on?October?15th?in?the?international?top?medical?journal?"The?BMJ?(British?Medical?Journal)".?Professor?Li?Yanbing?from?the?Department?of?Endocrinology?of?FAH-SYSU,?served?as?the?corresponding?author,?while?Associate?Chief?Physician?Liu?Liehua,?Attending?Physician?Ke?Weijian,?and?Associate?Chief?Physician?Li?Hai?from?the?same?hospital?were?the?first?authors.

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Traditionally,?diabetes?treatment?protocols?follow?a?stepup?approach,?involving?increasingly?complex?hypoglycemic?medications?to?address?progressive?blood?glucose?elevations?and?disease?progression.?However,?long-term?outcomes?have?been?unsatisfactory,?and?it?is?difficult?to?avoid?long-term?chronic?complications.?

Professor?Li?Yanbing's?team?has?been?focusing?on?diabetes?reversal?management?for?many?years?and?has?found?that?short-term?intensive?insulin?therapy?can?rapidly?eliminate?the?toxic?effects?of?hyperglycemia,?improve?islet?β-cell?function?and?insulin?sensitivity,?and?induce?diabetes?remission.?However,?if?not?managed?properly,?these?benefits?often?gradually?weaken?over?time.?Moreover,?many?patients?present?with?severe?hyperglycemia?at?diagnosis,?posing?greater?challenges?for?their?long-term?health?management.

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In?light?of?this,?the?research?team?designed?the?new?"intensive-simplified"?strategy,?which?involves?adopting?a?simplified?oral?hypoglycemic?drug?regimen?for?sequential?treatment?after?intensive?insulin?therapy?to?maintain?treatment?benefits?and?optimize?long-term?blood?glucose?control.

A?total?of?412?newly?diagnosed?patients?with?type?2?diabetes?were?enrolled?in?the?study.?All?subjects?first?underwent?short-term?intensive?insulin?therapy?for?two?weeks?to?normalize?blood?glucose?levels?and?eliminate?hyperglycemic?toxicity.?Subsequently,?subjects?were?randomized?into?four?treatment?groups.

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The?results?showed?that?the?combination?regimen?of?linagliptin?and?metformin?demonstrated?outstanding?advantages,?and?the?two?monotherapy?sequential?intervention?groups?also?achieved?good?glycemic?outcomes.?Meanwhile,?the?simplified?oral?medication?regimen?was?well?tolerated,?with?less?than?5%?of?subjects?quitting?treatment?due?to?adverse?reactions.

This?regimen?involves?fully?reversing?hyperglycemia?through?intensive?management?and?then?maintaining?it?with?a?simple?and?easy-to-administer?oral?medication?regimen?to?achieve?long-term?optimized?blood?glucose?control.?The?subsequent?simplified?management?avoids?multidrug?combination?therapy?or?even?injectable?treatments,?not?only?yielding?good?treatment?effects?but?also?significantly?improving?patient?compliance?and?helping?to?reduce?medical?expenses.

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報(bào)道時(shí)間：2024-10-21

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