韓安家
韓安家
職稱：主任醫(yī)師/教授
科室：病理科
簡(jiǎn)介：韓安家,，中山大學(xué)附屬第一醫(yī)院病理科/中山醫(yī)學(xué)院病理學(xué)教研室副主任。教授,、主任醫(yī)師,。擅長(zhǎng)軟組織腫瘤和呼吸系統(tǒng)疾病的病理診斷，主要從事結(jié)直腸癌和軟組織腫瘤發(fā)病機(jī)制研究。現(xiàn)任中華醫(yī)學(xué)會(huì)病理學(xué)分會(huì)第十屆委員會(huì)青年委員會(huì)副主任委員,，廣東省臨床病理質(zhì)量控制中心副主任兼秘書(shū),，廣東省醫(yī)學(xué)會(huì)病理學(xué)分會(huì)常委兼秘書(shū)，廣東省醫(yī)學(xué)會(huì)病理學(xué)分會(huì)軟組織和骨腫瘤病理協(xié)作組組長(zhǎng),。中華醫(yī)學(xué)會(huì)病理學(xué)分會(huì)軟組織和骨腫瘤病理學(xué)組（籌）委員,。國(guó)家自然科學(xué)基金、中國(guó)博士后科學(xué)基金,、廣東省自然科學(xué)基金,、北京市自然科學(xué)基金等項(xiàng)目評(píng)審專家。2004-2007年在University of Pittsburgh, Montefiore Medical Center, University of Illinois at Chicago作訪問(wèn)學(xué)者,。2012年在University of Texas Southwestern Medical Center進(jìn)行臨床觀摩學(xué)習(xí),。主持國(guó)家自然科學(xué)基金、廣東省自然科學(xué)基金等多項(xiàng),。近5年來(lái)在J PATHOL,，JNCI，EUR J CANCER,，INT J CANCER,，CARCINOGENESIS，MOL CARCINOGEN,，PLOS ONE等發(fā)表論著40余篇,。主編《軟組織腫瘤病理學(xué)診斷圖譜》（科學(xué)出版社，2014）,、 《病理學(xué)教學(xué)彩色圖譜》（科學(xué)出版社,，2003年）；參編《病理學(xué)高級(jí)教程》,、《病理學(xué)》（研究生用）,、《病理學(xué)與病理生理學(xué)》、《病理學(xué)與病理生理學(xué)學(xué)習(xí)指南》,、《外科病理學(xué)》,、《疑難外科病理診斷與鑒別診斷》、《現(xiàn)代肺癌病理與臨床》等多部,。擔(dān)任INT J CANCER, J MED VIROL, J Tumor,，《中華病理學(xué)》，《臨床與實(shí)驗(yàn)病理學(xué)雜志》,，《中華腫瘤防治雜志》等編委和特邀審稿專家,。獲《中華病理學(xué)雜志》50周年金筆獎(jiǎng)。
出診時(shí)間
專家門(mén)診
周一
Mon
周二
Tue
周三
Wed
周四
Thur
周五
Fri
周六
Sat
周日
Sun
上午
AM
下午
PM
出診時(shí)間以實(shí)際為準(zhǔn)

醫(yī)療專長(zhǎng)：

 

 

    韓安家,，中山大學(xué)附屬第一醫(yī)院病理科/中山醫(yī)學(xué)院病理學(xué)教研室副主任,。教授,、主任醫(yī)師。擅長(zhǎng)軟組織腫瘤和呼吸系統(tǒng)疾病的病理診斷,，主要從事結(jié)直腸癌和軟組織腫瘤發(fā)病機(jī)制研究?，F(xiàn)任中華醫(yī)學(xué)會(huì)病理學(xué)分會(huì)第十屆委員會(huì)青年委員會(huì)副主任委員，廣東省臨床病理質(zhì)量控制中心副主任兼秘書(shū),，廣東省醫(yī)學(xué)會(huì)病理學(xué)分會(huì)常委兼秘書(shū),，廣東省醫(yī)學(xué)會(huì)病理學(xué)分會(huì)軟組織和骨腫瘤病理協(xié)作組組長(zhǎng)。中華醫(yī)學(xué)會(huì)病理學(xué)分會(huì)軟組織和骨腫瘤病理學(xué)組（籌）委員,。國(guó)家自然科學(xué)基金,、中國(guó)博士后科學(xué)基金、廣東省自然科學(xué)基金,、北京市自然科學(xué)基金等項(xiàng)目評(píng)審專家,。2004-2007年在University of Pittsburgh, Montefiore Medical Center, University of Illinois at Chicago作訪問(wèn)學(xué)者。2012年在University of Texas Southwestern Medical Center進(jìn)行臨床觀摩學(xué)習(xí),。

主持國(guó)家自然科學(xué)基金,、廣東省自然科學(xué)基金等多項(xiàng)。近5年來(lái)在J PATHOL,，JNCI,，EUR J CANCER，INT J CANCER,，CARCINOGENESIS,，MOL CARCINOGEN，PLOS ONE等發(fā)表論著40余篇,。

主編《軟組織腫瘤病理學(xué)診斷圖譜》（科學(xué)出版社,，2014）、 《病理學(xué)教學(xué)彩色圖譜》（科學(xué)出版社,，2003年）,；參編《病理學(xué)高級(jí)教程》、《病理學(xué)》（研究生用）,、《病理學(xué)與病理生理學(xué)》,、《病理學(xué)與病理生理學(xué)學(xué)習(xí)指南》、《外科病理學(xué)》,、《疑難外科病理診斷與鑒別診斷》,、《現(xiàn)代肺癌病理與臨床》等多部。

擔(dān)任INT J CANCER, J MED VIROL, J Tumor,，《中華病理學(xué)》,，《臨床與實(shí)驗(yàn)病理學(xué)雜志》，《中華腫瘤防治雜志》等編委和特邀審稿專家,。獲《中華病理學(xué)雜志》50周年金筆獎(jiǎng)。

 

代表作 (*通訊作者):

  1. Zhen T, Dai S, Li H, Yang Y, Kang L, Shi H, Zhang F, Liang Y, Han A*. MACC1 promotes carcinogenesis of colorectal cancer via β-catenin signaling. Oncotarget. 2014 (advance online publications) （IF 6.636）
  2. Li H, Dai S, Zhen T, Shi H, Zhang F,Yang Y, Kang L, Liang Y, Han A*. Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. Eur J cancer 2014, 50(6):1207-1221 (IF 5.06)
  3. Cao Q, Liu F, Niu G, Xue L, Han A*. Blastic plasmacytoid dendritic cell neoplasm with EWSR1 gene rearrangement.J Clin Pathol. 2014 Jan;67(1):90-2. (IF 2.44)
  4. Yang Y, Li H, Zhang F, Shi H, Zhen T, Dai S, Kang L, Liang Y, Wang J, Han A*. Clinical and biological significance of hepatoma-derived growth factor in Ewing's sarcoma. J Pathol. 2013 Nov;231(3):323-34. (IF 7.59)
  5. Hu K, Liao D, Wu W, Han AJ, Shi HJ, Wang F, Wang X, Zhong L, Duan T, Wu Y, Cao J, Tang J, Sang Y, Wang L, Lv X, Xu S, Zhang RH, Deng WG, Li SP, Zeng YX, Kang T*.. Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma.Oncotarget 2013 Mar 21. [Epub ahead of print] （IF 6.636）
  6. Zhang F, Yang Q, Meng F, Shi H, Li H, Liang Y, Han A*. Astrocyte elevated gene-1 interacts with β-catenin and increases migration and invasion of colorectal carcinoma. Mol Carcinog. 2013 Aug;52(8):603-10 (IF 4.27)
  7. Meng F, Li H, Shi H, Yang Q, Zhang F, Yang Y, Kang L, Zhen T, Dai S, Dong Y, Han A*. MACC1 down-regulation inhibits proliferation and tumourigenicity of nasopharyngeal carcinoma cells through Akt/β-catenin signaling pathway. PLoS One. 2013;8(4):e60821. (IF 3.73)
  8. Yang Y, Zhen T, Zhang F, Dai S, Kang L, Liang Y, Xue L, Han A*. p53 and hepatoma-derived growth factor expression and their clinicopathological association with Ewing family tumour.J Clin Pathol. 2014 Mar;67(3):235-42 (IF 2.44)
  9. Chen W, Shi H, Liu Y, Ke Z, Han A*. Endotracheal angiomatoid 'malignant' fibrous histiocytoma: EWSR1 gene rearrangement.Pathology. 2013 Aug;45(5):506-8 (IF 2.66)
  10. Ye Z, Cao Q, Niu G, Liang Y, Liu Y, Jiang L, Yu X, Han A*. p63 and p53 expression in extranodal NK/T cell lymphoma, nasal type. J Clin Pathol. 2013 Aug;66(8):676-80. (IF 2.44)
  11. Tang QL, Xie XB, Wang J, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WG, Zhu XF, Zhou BP, Zeng YX, Shen JN, Kang T. Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma . J NATL CANCER I, 2012 May 16;104(10):749-63. (IF 14.34)
  12. Liu D, Shi H, Ke Z, Han A*. Primary cardiac diffuse large B-cell lymphoma, non-germinal centre B-cell type in an immunocompetent woman. Interact Cardiovasc Thorac Surg. 2012 Aug;15(2):282-4.
  13. Xiao P, Shi H, Zhang H, Meng F, Peng J, Ke Z, Wang K, Liu Y, Han A*. Epstein-Barr virus-associated intrahepatic cholangiocarcinoma bearing an intense lymphoplasmacytic infiltration. J Clin Pathol. 2012 Jun;65(6):570-3. (IF 2.44)
  14. Song Y, Yang QX, Zhang F, Meng F, Li H, Dong Y, Han A*. Suppression of nasopharyngeal carcinoma cell by targeting β-catenin signaling pathway. Cancer Epidemiol. 2012; 36(2):e116-21 (IF 2.23)
  15. Cai XD, Zhou YB, Huang LX, Zeng QL, Zhang LJ, Wang QQ, Li SL, Feng JQ, Han AJ. Reduced expression of Krüppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma. Biochem Biophys Res Commun. 2012 Feb 3;418(1):67-73. (IF 2.41)
  16. Sun S, Ke Z, Wang F, Li S, Chen W, Han A, Wang Z, Shi H, Wang LT, Chen X. Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Hum Pathol. 2012 Jul;43(7):1051-60. (IF 2.84)
  17. Wang Z, Yang S, Shi H, Du H, Xue L, Wang L, Dong Y, Han A*. Histopathological and immunophenotypic features of testicular tumour of the adrenogenital syndrome. Histopathology 2011;58(7):1013-8 (IF 2.86)
  18. Ye Z, Xiao Y, Shi H, Ke Z, Liu Y, Liang Y, Han A*. Sporadic Burkitt lymphoma in southern China: 12 years' experience in a single institution in Guangzhou. J Clin Pathol. 2011 Dec;64(12):1132-5. (IF 2.44)
  19. Zhang F, Meng F, Li H, Dong Y, Yang W, Han A*. Suppression of retinoid X receptor alpha and aberrant β-catenin expression significantly associates with progression of colorectal carcinoma. Eur J Cancer. 2011 Sep;47(13):2060-7. (IF 5.06)
  20. Ye C, Pan L, Huang Y, Ye R, Han A, Li S, Li X, Wang S. Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations. J Vasc Surg. 2011 Dec;54(6):1760-1768. (IF 2.88)
  21. Ye C, Yin H, Lin Y, Zhou L, Ye R, Li X, Han A, Wang S. Abdominal Aorta Aneurysms in Children: Single-Center Experience of Six Patients. Ann Thorac Surg. 2011 Jan;93(1):201-5 (IF 3.45)
  22. You S, Zhang F, Meng F, Li H, Liu Q, Liang Y, Dong Y, Yang W, Han A*. EBV-encoded LMP1 increases nuclear β-catenin accumulation and its transcriptional activity in nasopharyngeal carcinoma. Tumour Biol. 2011 Aug;32(4):623-30.PMID: 21336584(IF 2.52)
  23. Ye Z,Shi H, Peng T, Han A*.Clinical and pathological features of high grade primary cardiac osteosarcoma. Interact Cardiovasc Thorac Surg. 2011 Jan;12(1):94-5 PMID: 21098423
  24. Xiao P, Liu D, Peng J, Gao Z, Dong Y, Wu H, Han A*.  Aggressive angiomyxoma of sphenoidal sinus. Pathology 2011；43(1):79-81 PMID: 21240074 (IF 2.66)
  25. Liu D,Xiao P, Gao Z, Xue L, Wang L, Liu Y, Han A*.Chondroblastoma with adamantinoma differentiation of the calcaneus. Pathology 2011;43(2)：174-176 PMID: 21233685 (IF 2.66)
  26. Yang J, Zhang F, Fang H, Ye Z, Lin S, Han A*. Clinicopathologic features of primary lymphoma in soft tissue. Leuk Lymphoma. 2010 Nov;51(11):2039-46 PMID: 20929318 (IF 2.30)
  27. Fang HQ, Yang J, Zhang FF, Cui Y, Han AJ*. Clinical and Pathological features of Gastric glomus tumors. World J Gastroenterology, 2010,；16(36): 4616-4620 PMID: 20857536 (IF 2.55)
  28. Liu Q, Han A*, You S, Yang Q, Liang Y, Dong Y. The association of genomic variation of Epstein–Barr virus BamHI F fragment with the proliferation of nasopharyngeal carcinoma. APMIS 2010; 118(9):657-64. PMID: 20718717 (IF 2.07)
  29. Liu L, Wu J, Ying Z, Chen B, Han A, Liang Y, Song L, Yuan J, Li J, Li M. Astrocyte elevated gene-1 upregulates matrix metalloproteinase- 9 and induces human glioma invasion. Cancer Res. 2010; 70(9):3750-9 PMID: 20388776 (IF 8.65)
  30. Fang W, Han A, Bi X, Xiong B, Yang W. Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. Int J Cancer. 2010; 127(1): 32-42 PMID: 19904745 (IF 6.20)
  31. Hu D, Bi X, Fang W, Han A, Yang W. GSK3β is involved in JNK2-mediated β-catenin inhibition. PLoS One. 2009 Aug 13;4(8):e6640 PMID: 19675674 (IF 3.73)
  32. Wang Z, Yang Shicong, Wang LT, Han A*. Primary extrauterine undifferentiated endometrial sarcoma with osseous and cartilaginous differentiation. Pathology, 2009; 41(5):503-505 PMID: 19900096 (IF 2.66)
  33. Han A., Tong C., Hu D.,Bi X., Yang W. A direct protein-protein interaction is involved in the suppression of β-catenin transcription by retinoid X receptor α in colorectal cancer cells. Cancer Biol Ther. 2008; 7(3) 454-459 PMID: 181196974
  34. Han A.,，Song Z, Tong C, Hu D, Bi X, Augenlicht LH, Yang W.Sulindac suppresses β-catenin expression in human cancer cells. Eur J Pharmacol. 2008; 583(1) 26-31 PMID: 18291362
  35. Hu D, Fang W, Han A, Gallagher L, Davis RJ, Xiong B, Yang W. c-Jun NH2-terminal kinase 1 interacts with and negatively regulates Wnt/{beta}-catenin signaling through GSK3{beta} pathway. Carcinogenesis. 2008；29(12):2317-24 PMID: 18952597
  36. Feng C, Han A, Ye C, Xu R, Li M. The HMG-CoA Reductase Pathway, Statins and Angioprevention. Semin Ophthalmol. 2006, 21(1):29-35 PMID: 16517442
  37. Han AJ*, Xiong M, Gu YY, et al. Lymphoepithelioma-like carcinoma of the lung with a better prognosis: A clinicopathologic study of 32 cases. Am J Clin Pathol 2001,115(6): 841-850 PMID: 11392880
  38. Han AJ*, Xiong M, Zong YS. Association of Epstein-Barr Virus with lymphoepithelioma-like carcinoma of the lung in Southern China. Am J Clin Pathol 2000,114(2):220-226 PMID: 10941337