醫(yī)療/科研特長：
長期從事化學(xué)致癌表觀遺傳機(jī)制和腫瘤血管發(fā)生的信號傳導(dǎo)通路研究,，發(fā)表SCI論文40余篇，包括發(fā)表在J .Exp Med.,、Nat Med.,、Nat Commun.、JCI、 J Allergy Clin Immunol.,、Cancer Res.,、Oncogene、Carcinogenesis等國際著名專業(yè)期刊雜志,，主持國家,、省市各類科研項(xiàng)目10余項(xiàng)，獲科研成果獎勵9項(xiàng),。
研究方向：
化學(xué)致癌和膀胱癌的表觀遺傳機(jī)制
主要教育和工作經(jīng)歷：
1992年6月畢業(yè)于安徽醫(yī)科大學(xué),，獲預(yù)防醫(yī)學(xué)學(xué)士學(xué)位；2001年6月畢業(yè)于廣州醫(yī)科大學(xué),，獲衛(wèi)生毒理學(xué)碩士學(xué)位,；2008年6月畢業(yè)于中山大學(xué)，獲衛(wèi)生毒理學(xué)博士學(xué)位,；2001年7月至2014年5月在廣州醫(yī)科大學(xué)從事教學(xué)科研工作,， 2008年10月至2011年9月期間，在耶魯大學(xué)醫(yī)學(xué)院從事病理學(xué)博士后研究,； 2014年6月作為中山大學(xué)“百人計(jì)劃”人才引進(jìn)至中山大學(xué)附屬第一醫(yī)院轉(zhuǎn)化醫(yī)學(xué)研究中心工作,。
社會兼職：
國家自然科學(xué)基金面上項(xiàng)目和廣東省自然科學(xué)基金項(xiàng)目通訊評審專家，廣東省,、廣州市科技成果評審專家,；中國毒理學(xué)會生化與分子毒理專業(yè)委員會委員、中國轉(zhuǎn)化醫(yī)學(xué)聯(lián)盟理事,、廣東省轉(zhuǎn)化醫(yī)學(xué)會理事,、廣東省環(huán)境誘變劑學(xué)會理事、廣東省醫(yī)學(xué)會醫(yī)學(xué)科研實(shí)驗(yàn)室建設(shè)與管理分會委員,、廣東省醫(yī)院協(xié)會科研實(shí)驗(yàn)室建設(shè)與管理分會常委,。
論著：
1. Wei Y#, Zhang J#, Wu X, Sun W, Wei F, Liu W, Lu T, Ji W*, Li H*, Wen W*. Activated pyrin domain containing 3 (NLRP3) inflammasome in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP). J Allergy Clin Immunol. 2020;S0091-6749(20)30072-5.
2. Jin H#, Ying X#, Que B, Wang X, Chao Y, Zhang H, Yuan Z, Qi D, Lin S, Min W, Yang M*, Ji W*. N(6)-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer. EBioMedicine. 2019, 47:195-207. PMID: 31409574.
3. Yang F#, Jin H#, Que B#, Chao Y#, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W*, Lin S*, Ji W*. Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis. Oncogene. 2019;38(24):4755-4772.
4. Chao Y, Shang J*, Ji W*. ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia. Biochem Biophys Res Commun. 2020; 521(2):499-506.
5. Yuan G, Chen T, Zhang H, Cao Q, Qiu Y, Que B, Peng S, Chen M*, Ji W*. Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma. Mol Carcinog. 2018 Sep 4. doi:10.1002/mc.22900.
6. Zhang H, Qi D, Li J, Peng T, Yang L, Yuan J, Zhang Y, Hu Y, Su J, Que B, Li M, Zhou G, Chen Y, Zhang W*, Ji W*. A novel regulatory circuit of miR?152 and DNMT1 in human bladder cancer. Oncol Rep. 2018 Sep;40(3):1803-1812.
7. He J, Huang S, Lin Z, Zhang J, Su J, Ji W*, Liu X*. Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells. Oncol Lett. 2018 Jul;16(1):703-712.
8. Mingzhu Yin, Huanjiao Jenny Zhou, Jiqin Zhang, Caixia Lin, Hongmei Li, Xia Li, Yonghao Li, Haifeng Zhang, David G. Breckenridge, Ji W, and Wang Min*,ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis, 2017.
9. Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, Xu X, Zhang H, Santin AD, Lou G, Min W*. Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. J Clin Invest. 2016 Nov 1;126(11):4157-4173.
10. Qi D, Li J, Que B, Su J, Li M, Zhang C, Yang M, Zhou G, Ji W*. Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer. Cancer Cell Int. 2016 Oct 18;16:81.
11. Zhou HJ, Qin L, Zhang H, Tang W, Ji W, He Y, Liang X, Wang Z, Yuan Q, Vortmeyer A, Toomre D, Fuh G, Yan M, Kluger MS, Wu D*, Min W*. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016 Sep;22(9):1033-42.
12. Gao Y, Yin Y, Xing X, Zhao Z, Lu Y, Sun Y, Zhuang Z, Wang M, Ji W*, He Y*. Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3. Toxicol Lett. 2016 Jul 8;254:22-31.
13. Chen Y, Zhang H, Zhou HJ, Ji W, Min W*. Mitochondrial Redox Signaling and TumorProgression. Cancers (Basel). 2016 Mar 25;8(4). pii: E40.
14. Shao L, Zhou HJ, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W*. SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nat Commun. 2015 Nov 24;6:8917.
15. Ji W, Li Y, He Y, Yin M, Zhou HJ, Boggon TJ, Zhang H, Min W*. AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis.[J]. Cancer Research, 2015, 75(17):3492-504.
16. Ji W, Yang M, Praggastis A, Li Y, Zhou HJ, He Y, Ghazvinian R, Cincotta DJ, Rice KP, Min W. Carbamoylating Activity Associated with the Activation of the Antitumor Agent Laromustine Inhibits Angiogenesis by Inducing ASK1-Dependent Endothelial Cell Death. PLoS One. 2014 Jul 28;9(7):e103224.
17. Qi D, Hu Y, Zhang Y, Peng T, Ji W*.Effect of Ku70 expression on radiosensitivity in renal carcinoma 786-O cells. Cancer Cell Int. 2014 May 26;14:44.
18. Ji W*，Yang L , Yuan J , Yang L , Qi D , Zhang M , Lu J , Zhuang Z , Zeng G* .MiRNA-152 Targets DNA Methyltransferase 1 in NiS-transformed Cells via a Feedback Mechanism . Carcinogenesis . 2013.34(2):446-53.
19. Ji W #, Li Y # , Wan T , Wang J , Zhang H , Chen H* , Min W* . Both Internalization and AIP1 Association Are Required for Tumor Necrosis Factor Receptor 2-Mediated JNK Signaling . Arterioscler Thromb Vasc Biol . 2012.32(9):2271-9.
20. Yang L , Li Y , Ling X , Liu L , Liu B , Xu K , Bin X , Ji W*, Lu J * . A Common Genetic Variant (97906C>A) of DAB2IP/AIP1 Is Associated with an Increased Risk and Early Onset of Lung Cancer in Chinese Males . PLoS One . 2011.6(10):e26944.
21. Yu L # , Ji W #, Zhang H, Renda MJ , He Y , Lin S , Cheng EC , Chen H , Krause DS , Min W* . SENP1-mediated GATA1 desumoylation is critical for definitive erythropoiesis . J Exp Med . 2010.207(6):1183-95.
22. Ji W,， Yang L , Yu L , Yuan J , Hu D , Zhang W , Yang J , Pang Y , Li W , Lu J , Fu J , Chen J , Lin Z , Chen W* , Zhuang Z* . Epigenetic silencing of O6-methylguanine DNA methyltransferase in nickel-transformed cells. Carcinogenesis. 2008.29(6):1267-75.
23. Yang L, Yang X, Ji W, Deng J, Qiu F, Yang R, Fang W, Zhang L, Huang D, Xie C, Zhang H, Zhong N, Ran P, Zhou Y, Lu J*. Effects of a Functional Variant c.353T>C in Snai1 on Risk of Two Contextual Diseases. Chronic Obstructive Pulmonary Disease and Lung Cancer. Am J Respir Crit Care Med. 2014.189(2):139-48.
24. Liu B # , Yang L # , Huang B , Cheng M , Wang H , Li Y , Huang D , Zheng J , Li Q , Zhang X , Ji W , Zhou Y , Lu J *. A Functional Copy-Number Variation in MAPKAPK2 Predicts Risk and Prognosis of Lung Cancer . Am J Hum Genet . 2012.91(2):384-90.
專著：
其他主要工作成績（比如獲獎情況）：
主持5項(xiàng)國家自然科學(xué)基金面上項(xiàng)目和省,、市等各類項(xiàng)目共計(jì)10余項(xiàng)；申請發(fā)明專利5項(xiàng),。
獲獎情況：
1.《典型環(huán)境毒物的表觀遺傳效應(yīng)研究》,，廣東省科技進(jìn)步獎二等獎（第二完成人）2014
2.《結(jié)晶型NiS誘發(fā)的轉(zhuǎn)化細(xì)胞中MGMT基因表觀遺傳調(diào)控》，第二屆南粵科技創(chuàng)新優(yōu)秀學(xué)術(shù)論文一等獎（第一完成人）2011
3.《肺癌化學(xué)病因及其干預(yù)的實(shí)驗(yàn)研究》,，廣東省科技進(jìn)步二等獎,、廣州市科技進(jìn)步一等獎、中華預(yù)防醫(yī)學(xué)會科技進(jìn)步三等獎（第三完成人）2008,、2007,，
4.《結(jié)晶型NiS誘發(fā)人支氣管上皮細(xì)胞系惡性轉(zhuǎn)化》,，中國毒理學(xué)會中青年優(yōu)秀論文獎,，（第一完成人） 2001
5.《鎳化合物致癌分子機(jī)制系列研究》,，廣州市科技進(jìn)步二等獎（第二完成人），2006
6.《Epigenetic silencing of O6-methylguanine DNA methyltransferase in nickel-transformed cells》,， The 4th International Congress of Asian Society of Toxicology,， Best Poster Award, （第一完成人）2006
7.《代表性環(huán)境化學(xué)污染物致DNA損傷修復(fù)機(jī)制及相關(guān)基因多態(tài)性研究》，中華醫(yī)學(xué)會科技進(jìn)步三等獎（第四完成人）,，2011
