醫(yī)療/科研特長：
長期從事慢性免疫病研究,，在艾默里大學和斯坦福大學工作期間，發(fā)現(xiàn)了自身免疫病病人免疫細胞中ATM蛋白主導的DNA 損傷修復通路的缺陷可導致免疫細胞修復功能的缺失,免疫系統(tǒng)長期處于增殖壓力下,，最終導致免疫衰老和自身免疫識別的異常,。此發(fā)現(xiàn)從一定程度改變了傳統(tǒng)上人們對自身免疫病的認識,。在美國耶魯大學醫(yī)學院工作期間,，深入研究了表觀遺傳修飾酶--SUMO特異性蛋白酶（SENP1），并首次證明了NEMO的SUMO化特異性增強胰島脂肪細胞炎性細胞介素的分泌,，進而導致自發(fā)性糖尿病,，從而首次揭示SENP1作為敏感基因在糖尿病發(fā)病中的作用。相關結果分別發(fā)表在J .Exp Med.,，Nature Communication,，Nature Review Rheumatology，PNAS,，EMBO MM, Journal of Autoimmunity. Arthritis & rheumatism., Frontiers in Immunology等國際著名的醫(yī)學雜志,。并被美國臨床免疫學會（FOCIS），美國免疫學會（AAI）,，美國類風濕學會（ACR）邀請作大會報告,。此外還擁有斯坦福大學技術許可證明1項，美國專利1項及國內(nèi)專利2項,。
研究方向：臨床免疫學及腫瘤免疫
主要教育和工作經(jīng)歷：
沈陽藥科大學 藥學 學士
沈陽藥科大學 藥理 碩士
中科院研究生院 細胞生物學 博士
2002.8-2007.3 中科院動物所 助理研究員
2006.4-2009.12 艾默里大學（Emory） 博士后
2009.12-2011.6 斯坦福大學（Stanford）博士后
2011.4-2012.4 斯坦福大學（Stanford）研究助理
2012.8-2016.3 耶魯大學（Yale） 副研究員
2016.4-至今 中山大學 研究員
社會兼職：
論著：
1 Qiao Su#, jun Jing#, Wuguo Li, Jianda Ma, Xueling zhang, Zongren Wang, Zhongyang Zhou, Lie Dai*, Lan Shao*, Impaired Tip60-mediated Foxp3 acetylation attenuates regulatory T cell development in rheumatoid arthritis, Journal of Autoimmunity, 2019, 100, 27-29. (IF: 7.54)
2 Jian‐Da Ma, Jun Jing, Jun‐Wei Wang, Ying-Qian Mo, Qian‐Hua Li, Jian‐Zi Lin, Le‐Feng Shao L *#, Pierre Miossec, Lie Dai# . Activation of the PGC‐1β/NFATc‐1 Pathway in Circulating Osteoclast Precursors Associated with Bone Destruction in Rheumatoid Arthritis. Arthritis & rheumatism. 2019 Aug;71(8):1252-1264.(IF: 9.02)
3 Shao L * DNA damage response signals transduce stress from rheumatoid arthritis risk factors into T cell dysfunction. Frontiers in immunology. Frontiers in immunology. 2018, December, Vol: 9:3055
4 張雪玲,，李武國，周仲洋,，鄭漫妮,，邵蘭*. T 細胞代謝異常對類風濕關節(jié)炎發(fā)生發(fā)展影響。中華風濕病學雜志. 2018, 22(11), 114-116.1
5 Shao L, Feng BY, Zhou HJ, Ji WD, Wang Min* The role of adipose derived inflammatory cytokines in type 1 diabetes (2016). Adipocyte 17 Mar 2016:1-5. (IF: 3.55)
6 邵蘭,，馮博雅, 張鈺瑩, 周煥嬌,，紀衛(wèi)東，王敏(2016).脂肪組織與Ⅰ型糖尿病,。千人生物2016, 3(1), 1-6,。
7 Shao L, Zhou HJ, Zhang HF, Wang Min (2015). SENP1-mediated NEMO deSUMOyation in the adipocyte limits inflammatory responses and type 1 diabetes progression. Nat. Commun. 2015, Nov 24. (IF: 12.12)
8 Shao L, Goronzy JJ, Weyand CM (2010). Inhibition of the DNA repair enzyme DNA-PKcs restores T cell survival in rheumatoid arthritis. EMBO Molecular Medicine. 2010 2 (10):415-27. (IF: 11.549)
9 Goronzy JJ, Shao L, Weyand CM (2010). New insights into Rheumatoid Arthritis. Rheumatic Disease Clinics of North America. 2010 36 (2). 297-310. (IF: 3.34)
10 Shao L, Fujii H, Goronzy JJ, Weyand CM (2009). Deficiency of the DNA repair enzyme ATM in Rheumatoid Arthritis. J.Exp.Med. 2009 Jun; 8; 206(6): 1435-49. (IF: 11.9)
11 Weyand CM, Fujii H, Shao L, Goronzy JJ (2009).Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol. 2009 5, 583-588. (IF: 18.68)
12 Fujii H, Shao L, Goronzy JJ, Weyand CM (2009). Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11): 4360-5. (IF: 9.81)
13 Shao L, Li QH, Wang J, Tan Z (2005). Fragmentation and rapid shortening of telomere in HeLa cells in the early phase of hydroxyl radical-induced apoptosis. Cancer Biol Ther. 2005; 4(3):336-41.(IF: 3.63)
14 Shao L, Li QH, Tan Z (2004). L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004, 324(2): 931-936.(IF: 2.4)
15 Yang F, Yang JP, Li QH, Shao L (2003). Strand breaks in telomeres in Hela cells. Acta Zoology Sinica. 2003, 49 (6): 873-877.
16 Shao L, Huang Q, Li QH (2003). Regulation effect of insulin on metabolic dysfunction of diabetic rats. Chinese Journal of Zoology. 2003, 38(2): 23-27.
17 Shao L, Li QH, Huang Q (2002). Effect of insulin on oxidative damage in liver of diabetic rats. Chinese Journal of Zoology. 2002, 37(5): 28-31.
18 Jiao XM, Li QH, Xu M, Li LJ, Shao L (2002). Fusion of Ehrlich′s ascites cell plasma membrane with liposomes driven by transmembrane pronton efflux: effect of calcium ions and liposome phospholipid composition. Acta Zoologica Sinica. 2002, 48 (5): 660-666.
19 Huang Q, Shao L, Jiang H (2001). Effect of insulin on oxygen free radicals and oxidative phosphorylation in liver mitochondrial of diabetic rats. Acta. Pharmacol. Sina. 2001, 22(5): 455-458. (IF:2.496)
20 Shao L, Yu QH, Huang Q (2001). The effect of Houttuyninum on cellular immunological function in splenectomy animals. Chinese Pharmacological Bullitin.2001, 17(1): 51-54.
21 Shao L,Yu QH (2000). The effect of Houttuyninum on immunological function in mice treated with cyclophosphamide. Journal of Shenyang Pharmacoeuticel University. 2000, 17(2): 133-135.
22 Shao L,Yu QH (1999). The effect of Houttuyninum on immunological function in splenectomy animals. Journal of Shenyang Pharmacoeuticel University. 1999, 16(3): 209-211.
23 Shao L,Yu QH (1998). The Improving Effect of Decoction of Coptis and Its Extract on Intelligence.Journal of Shenyang Pharmacoeuticel University. 1998, 15 (1): 35~37.
24 Ye FG, Yu QH, Shao L (1998). Antioxidant Activity of Calculus Borisfor Lipid. China Journal of Traditional Chinese Medicine and Pharmacy. 1998, 13 (2): 69.
25 Yu QH, Zhang YF, Shao L (1997). The role of Immune regulation of Chinese Medicine. Medical Journal of Liaoning. 1997, 11(6): 299-301.
專利
1 Weyand CM, Goronzy JJ, Shao L. Improving Immune System Function in conditions characterized by elevated double strand breaks (U.S. Patent Application Serial No. 13/205,001, issued data 12/6/2016).
2 Zhao Y, Xie W, Shao L. A tetramer combined with SARS Antigen Peptide, its preparation and use (No. 200310113727).
其他主要工作成績：
中山大學附屬第一醫(yī)院 2015高影響因子獎
美國免疫學年會大會獎（AAI 2010）
美國臨床免疫學年會大會獎 (FOCIS 2009)
