醫(yī)療特長：從事消化內(nèi)科臨床工作30余年,；具有豐富的臨床經(jīng)驗(yàn)，致力胃食管反流病,，消化性潰瘍等酸相關(guān)性疾病以及肝膽疾病的診治,。擅長各類消化系統(tǒng)常見疾病，包括胃食管反流病,、慢性胃炎,、賁門失弛緩癥、功能性食管疾病,、消化性潰瘍,、急性腸炎、腸易激綜合征,、肝炎,、脂肪肝、膽囊炎,、膽管炎等,。熟悉掌握消化內(nèi)鏡檢查及治療。
主要教育和工作經(jīng)歷：
教授,，主任醫(yī)師,，博士生導(dǎo)師。中山大學(xué)內(nèi)科學(xué)博士研究生,，美國西南醫(yī)學(xué)中心基礎(chǔ)研究訪問學(xué)者,、英國伯明翰大學(xué)臨床研究訪問學(xué)者?，F(xiàn)任中山大學(xué)附屬第一醫(yī)院精準(zhǔn)醫(yī)學(xué)研究院副院長、藥物臨床試驗(yàn)機(jī)構(gòu)主任,、臨床研究中心副主任,。中國醫(yī)院協(xié)會健康醫(yī)療大數(shù)據(jù)應(yīng)用管理專委會常委、廣東省干（體）細(xì)胞臨床研究專家委員會委員,。
論著：
迄今以第一作者或通訊作者（含共同通訊）發(fā)表論著40 余篇,，分布在Lancet Digital Health、Hepatology,、Annals of Oncology,、Clinical Cancer Research、American Journal of Gastroenterology等國際權(quán)威學(xué)術(shù)期刊,。主持國自然面上及廣東省工信廳財(cái)政專項(xiàng)等國家及省部級資金項(xiàng)目,，獲資助超1200萬?；趯,？葡盗醒芯浚群髽s獲2018年國際消化疾病協(xié)會杰出學(xué)者獎,，多項(xiàng)研究成果被國際消化病診治指南推薦,，2019年獲得廣東省科技進(jìn)步一等獎。
(1) Xiang X, Hao Y, Cheng C, Hu H, Chen H, Tan J, Wang Y, Liu X, Peng B, Liao J, Wang J, Xie Y, Liu J, Chen S, Xu L, Xie W, Xue R, Kuang M, Xu Z, Jiang H, Peng S. A TGF-β-dominant chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children. Hepatology. 2024 Mar 1;79(3):650-665. doi: 10.1097/HEP.0000000000000534. Epub 2023 Jul 17. PMID: 37459556.
（2）Xiao H, Weng Z, Sun K, Shen J, Lin J, Chen S, Li B, Shi Y, Kuang M, Song X, Weng W, Peng S. Predicting 5-year recurrence risk in colorectal cancer: development and validation of a histology-based deep learning approach. Br J Cancer. 2024 Apr;130(6):951-960. doi: 10.1038/s41416-024-02573-2. Epub 2024 Jan 20. PMID: 38245662; PMCID: PMC10951272.
（3）Wang Y, Xiang X, Chen H, Zhou L, Chen S, Zhang G, Liu X, Ren X, Liu J, Kuang M, Jiang J, She J, Zhang Z, Xue R, Jiang H, Wang J, Peng S. Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma. Cell Rep Med. 2023 May 16;4(5):101044. doi: 10.1016/j.xcrm.2023.101044. PMID: 37196629; PMCID: PMC10213871.
（4）Chen Z, Zhang G, Ren X, Yao Z, Zhou Q, Ren X, Chen S, Xu L, Sun K, Zeng Q, Kuang M, Kuang DM, Peng S. Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer. Cancer Res. 2023 Nov 1;83(21):3544-3561. doi: 10.1158/0008-5472.CAN-23-0193. PMID: 37352379.
（5）Peng H, Chen B, Wei W, Guo S, Han H, Yang C, Ma J, Wang L, Peng S, Kuang M, Lin S. N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation. Nat Metab. 2022 Aug;4(8):1041-1054. doi: 10.1038/s42255-022-00622-9. Epub 2022 Aug 23. PMID: 35999469.
（6）Peng S, Chen S, Hu W, Mei J, Zeng X, Su T, Wang W, Chen Z, Xiao H, Zhou Q, Li B, Xie Y, Hu H, He M, Han Y, Tang L, Ma Y, Li X, Zhou X, Dai Z, Liu Z, Tan J, Xu L, Li S, Shen S, Li D, Lai J, Peng B, Peng Z, Kuang M. Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma. Cancer Immunol Res. 2022 Jun 3;10(6):728-744. doi: 10.1158/2326-6066.CIR-21-0931. PMID: 35476700.
（7）Chen S, Xie Y, Cai Y, Hu H, He M, Liu L, Liao C, Wang Y, Wang J, Ren X, Zeng Q, Peng H, Shen S, Li S, Li D, Lai J, Peng B, Ren J, Kuang M, Peng S. Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma. Clin Cancer Res. 2022 May 2;28(9):1896-1910. doi: 10.1158/1078-0432.CCR-21-1157. PMID: 34526363.
（8）Wang F, Wang FH, Sun K, Jiang C, Peng S, Xu LX, Kuang M, Guo GF, Chen SL. PD-1-mAb Plus Regimen in the First and Second Lines of Advanced and Unresectable Biliary Tract Carcinoma: A Real-World, Multicenter Retrospective Analysis. J Inflamm Res. 2022 Oct 31;15:6031-6046. doi: 10.2147/JIR.S364303. PMID: 36339826; PMCID: PMC9635481.
（9）Wang J, Deng C, Liu M, Liu Y, Li L, Huang Z, Shang L, Jiang J, Li Y, Mo R, Zhang H, Liu M, Peng S, Xiao H. A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain. Nat Commun. 2022 Nov 11;13(1):6866. doi: 10.1038/s41467-022-34633-7. PMID: 36369243; PMCID: PMC9651894.
（10）Liu Y, Zhang H, Yuan G, Yao M, Li B, Chen J, Fan Y, Mo R, Lai F, Chen X, Li M, Chen B, Lord JM, Peng S, Cheng K, Xiao H. The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial. Immun Ageing. 2022 Oct 17;19(1):46. doi: 10.1186/s12979-022-00304-w. PMID: 36253778; PMCID: PMC9574181.
（11）Chu H, Liu Z, Liang W, Zhou Q, Zhang Y, Lei K, Tang M, Cao Y, Chen S, Peng S, Kuang M. Radiomics using CT images for preoperative prediction of futile resection in intrahepatic chol15angiocarcinoma. Eur Radiol. 2021 Apr;31(4):2368-2376. doi: 10.1007/s00330-020-07250-5. Epub 2020 Oct 8. PMID: 33033863.
（12）Chu H, Liu Z, Liang W, Zhou Q, Zhang Y, Lei K, Tang M, Cao Y, Chen S, Peng S, Kuang M. Radiomics using CT images for preoperative prediction of futile resection in intrahepatic cholangiocarcinoma. Eur Radiol. 2021 Apr;31(4):2368-2376. doi: 10.1007/s00330-020-07250-5. Epub 2020 Oct 8. PMID: 33033863.
（13）Peng S, Liu Y, Lv W, Liu L, Zhou Q, Yang H, Ren J, Liu G, Wang X, Zhang X, Du Q, Nie F, Huang G, Guo Y, Li J, Liang J, Hu H, Xiao H, Liu Z, Lai F, Zheng Q, Wang H, Li Y, Alexander EK, Wang W, Xiao H. Deep learning-based artificial intelligence model to assist thyroid nodule diagnosis and management: a multicentre diagnostic study. Lancet Digit Health. 2021 Apr;3(4):e250-e259. doi: 10.1016/S2589-7500(21)00041-8. Erratum in: Lancet Digit Health. 2021 Jul;3(7):e413. PMID: 33766289.
（14）Chen SL, Xiao H, Xie ZL, Shen JX, Chen ZB, Wang YQ, Li B, Peng ZW, Kuang M, Lai JM, Peng S. The presence of microvascular invasion guides treatment strategy in recurrent HBV-related HCC. Eur Radiol. 2020 Jun;30(6):3473-3485. doi: 10.1007/s00330-019-06640-8. Epub 2020 Feb 11. PMID: 32048035.
（15）Huang M, He M, Guo Y, Li H, Shen S, Xie Y, Li X, Xiao H, Fang L, Li D, Peng B, Liang L, Yu J, Kuang M, Xu L, Peng S. The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas. Clin Cancer Res. 2020 Sep 15;26(18):4947-4957. doi: 10.1158/1078-0432.CCR-19-3840. Epub 2020 Jun 11. PMID: 32527942.
（16）Xu LX, He MH, Dai ZH, Yu J, Wang JG, Li XC, Jiang BB, Ke ZF, Su TH, Peng ZW, Guo Y, Chen ZB, Chen SL, Peng S, Kuang M. Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma. Ann Oncol. 2019 Jun 1;30(6):990-997. doi: 10.1093/annonc/mdz103. PMID: 30916311; PMCID: PMC6594462.
（17）Liao J, Jin H, Li S, Xu L, Peng Z, Wei G, Long J, Guo Y, Kuang M, Zhou Q, Peng S. Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019 Nov 6;38(1):454. doi: 10.1186/s13046-019-1419-1. PMID: 31694662; PMCID: PMC6836669.
